【摘要】 目的:观察养心通脉方(YX)对慢性心力衰竭大鼠心功能和血流动力学的作用。方法:复制结扎左冠状动脉主干所致急性心肌梗死(AMI)后慢性心衰大鼠(CHFR)模型,测定YX对CHFR心功能与血流动力学的影响。结果:YX能明显提高CHFR的左室内压峰值(LVSP)、动脉收缩压(SAP)、平均动脉压(MAP)和左室内压最大上升速率(+dp/dtmax),P<0.05～0.01;能明显降低左室舒张末期压(LVEDP)、心室开始收缩到压力上升速率最大值的时间(t～dp/dtmax),P<0.05～0.01。结论:YX能明显增加CHFR心肌收缩力,改善心功能与血流动力学。更多还原

【Abstract】 OBJECTIVE:To observe the influence of Yang Xin Tong Mai Prescription (YX) upon cardiac function and hemodynamics of chronic heart failure rats.METHOD:CHFR simulating models because of AMI caused by ligation of main branch of left coronary artery were used to find out the influence of YX upon cardiac function and hemodynamics.RESULT:YX had an obvious influence on CHFR in raising LVSP,SAP,MAP and utmost ascending rate of left ventricle inner pressure.(+dp/dtmax), ( P <0.05～0.01).CONCLUSION:CHFR cardiac muscular contraction could be strengthened, cardiac function and hemodynamics be improved by XY.更多还原