【摘要】 目的　研究大鼠侧脑室内注射 (icv)神经降压素 (NT)所致降压反应的中枢机制。方法　用乌拉坦麻醉雄性 SD大鼠 (3 0只 ) ,将 NT icv,观察其血压 (BP)和心率 (HR)的变化。然后分别 icv M受体阻断剂硫酸阿托品和切断两侧颈部迷走神经 ,再 icv NT,观察 BP和 HR的变化。结果　 icv NT (10μg/鼠 )可引起 BP升高或降低 ,HR减慢。预先 icv阿托品 2 .5μg,可阻断 NT的中枢降压反应 ;切断两侧颈部迷走神经可减弱 NT的中枢心血管抑制效应。结论　脑中 NT含量升高可使血压升高或降低 ,NT引起的中枢心血管抑制效应主要是由于心迷走神经系统活动加强所致更多还原

【Abstract】 Objective To investigate the mechanism of depressor response induced by central injection of neurotensin (NT) in rats. Methods Arterial blood pressure (BP) and heart rate (HR) responses followed by lateral cerebroventricular injection (icv) of NT (10 μg/rat) of male SD rats anaesthetized with urethane ( n =30) were measured. Results icv of NT (10 μg/rat) could either induce a rise or a decrease of BP and a slowing down of HR. The central depressor response to NT could be blocked by pretreatment with M receptor blocker atropine (2.5 μg, icv) and markedly decreased by bilateral cervical vagotomy. Conclution The central depressor response to NT is induced by the strengthening of the activities of cardiac vagus nerve system.更多还原