【摘要】 目的:建立模拟人类感染幽门螺杆菌的小鼠动物模型。方法:选用来自复合性溃疡患者的幽门螺杆菌临床新鲜分离株,以109 CFU·ml1 的菌量按Marta 等报道的方法接种Balb/c 小鼠,最后1 次接种后5 d、2 周、3 周、4 周分别进行检测。结果:接种幽门螺杆菌的实验小鼠胃粘膜均分离出幽门螺杆菌,病理切片显示实验小鼠胃粘膜有不同程度的炎性细胞浸润。结论:选用幽门螺杆菌临床新鲜分离株,按一定方法给小鼠接种,可导致小鼠发生胃炎更多还原

【Abstract】 Objective:The purpose of the experiment was to try to establish a mouse model of Helicobacter pylori(Hp) infection that mimics human disease.Method:Balb/c mice were inoculated with fresh clinical isolates of Hp according to Marta’s method.Results: Hp was detected only in the inoculated group.Gastritis was observed only in the inoculated group with Hp strains.Conclusion:A mouse model of Hp infection can be got by inoculation with fresh clinical isolates of Hp were according to Marta’s method.更多还原