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双歧杆菌细胞壁与富锗灵芝的协同抑瘤作用

On Coordinated Anti-Tumor Effect of the Glossy Ganoderma Rich in Germanium and the Cell Wall of Bifidobacterium

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【作者】 史俊华; 赵宇; 阮国瑞; 张雪萍; 王思一; 葛培玲; 潘浩;

【Author】 Shi Junhua,Zhao Yu,Ruan Guorui,Zhang Xueping,Wang Siyi,Ge Peiling (Department of Microbiology,Nanjing Railway Medical College,Nanjing,210009) Pan Hao (Sanitary and Anti-epidemic Station,Jiangsu Province,Nanjing,210009)

【机构】 南京铁道医学院微生物学教研室!南京210009; 江苏省卫生防疫?;

【摘要】 目的:双歧杆菌细胞壁与富锗灵芝联合应用于荷瘤动物体内,观察抑瘤效果。方法:将纯系小鼠随机分4 组,建立 S180 实体瘤模型后,分别用双歧杆菌细胞壁及双歧杆菌细胞壁加富锗灵芝进行治疗。结果:检测巨噬细胞活性及干扰素活性均有明显的升高。结论:双歧杆菌细胞壁加富锗灵芝比单独应用双歧杆菌细胞壁对机体的免疫促进作用更为明显。

【Abstract】 Objective:A strain of Bifidobacterium and its cell wall were used to treat the Balb/c mice bearing S180 sarcoma in order to investigate the anti-tumor effect of them.Method:The activities of macrophage (M) and the level of interferon (IFN) were measured on day 13 after treatment of mice with the cell wall of Bifidobacterium ( B ?CW) with or without glossy ganoderma rich in germanium.Result:The activities of M and the level of IFN were improved compared with control group.Conclusion: B ?CW with glossy ganoderma rich in germanium has more effect on improving immunity of the body than B ?CW used alone.

【关键词】 双歧杆菌; 锗; 灵芝; 肿瘤; 小鼠;
【Key words】 Bifidobacterium; germanium; glossy ganoderma; sarcoma; mice;
【基金】 铁道部科技基金
  • 【文献出处】 南京铁道医学院学报 ,JOURNAL OF NANJING RAILWAY MEDICAL COLLEGE , 编辑部邮箱 ,1999年03期
  • 【分类号】R730.52
  • 【下载频次】62
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