【摘要】 将ＤＬ－苯丙氨酸与甲醇酯化得ＤＬ－苯丙氨酸甲酯盐酸盐，在甲苯／水两相体系中用碳酸氢钠中和ＤＬ－苯丙氨酸甲酯盐酸盐得游离ＤＬ－苯丙氨酸甲酯，在甲苯／水两相体系中用胰酶拆分ＤＬ－苯丙氨酸甲酯得到Ｌ－苯丙氨酸和Ｄ－苯丙氨酸甲酯，取得了各步反应的最优条件，并将Ｄ－苯丙氨酸甲酯外消旋得到ＤＬ－苯丙氨酸甲酯继续用于拆分。拆分摩尔收率为６１．４％，所得Ｌ－苯丙氨酸粗品纯度为９２．２％，重结晶后为９８．６％，［α］２５Ｄ＝－３０．５°更多还原

【Abstract】 DLphenylalanine is esterfied with methanol in the presence of hydrogen chloride, and the methyl DLester hydrochloride is then neutralized with sodium bicarbonate. Through resolution of DLester with pancreatin in toluene/water biphasic system, Lphenylalanine and Dester are obtained. All the optimum conditions are reached. In addition, the Dester in toluene can be racemized for recycling. The Lphenylalanine has 56.6% yield and 98.6% purity, \+\{25\}\-D=-30.5.\=更多还原