【摘要】 应用ＰＣＲ／ＳＳＯ方法对５１例经肾穿刺证实ＩｇＡ 肾病患者和９６名健康对照人员进行了ＨＬＡ－ＤＱＢ１等位基因分型。结果显示ＩｇＡＮ 患者组中ＤＱＢ１０３０２基因频率明显高于正常对照组（Ｐｃ ＜ ０．００１，ＲＲ为８．２０）；ＩｇＡＮ患者组中ＤＲ４、ＤＱＢ１０３０２均为阳性的表型频率也明显高于对照组（Ｐ＜ ０．００１，ＲＲ为６．４３），而ＤＲ４阳性、ＤＱＢ１０３０２阴性的表型频率在两组中无差异。推测ＤＱＢ１０３０２等位基因可能与上海汉族ＩｇＡＮ的发病有一定的关联。更多还原

【Abstract】 We determined HLA DQB1 alleles of 51 adult patients with biopsy proved primary IgA Nephropathy and 96 healthy controls using PCR/SSO method.The results showed that DQB1 0302 allele frequency was si gnificantly increased in the IgAN patients than in the healthy controls( P c <0.001,RR=8.20),while DR4、DQB1 0302 of the phenotype frequency significantly increased in the IgAN patients compared with healthy controls( P <0.001,RR=6.43).The data demonstrate DQB1 0302 allele has an association to disease IgAN.更多还原