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损伤血管中血管紧张素原基因的表达

Expression of angiotensinogen gene in injury vessels

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【作者】 张雪怡陈迁周爱儒

【Author】 Zhang Xueyi;Chen Qian;Zhou Airu.(Deptment of biochemistry, north china coal medical college,Tangshan, 063000)

【机构】 华北煤炭医学院基础部生物化学教研室!唐山063000华北煤炭医学院科研处!唐山北京医科大学

【摘要】 目的测定损伤血管中血管紧张素原基因的表述状况,进一步阐明局部肾素-血管紧张系统(RAS)在损伤诱导的VSMC增殖中的作用。方法在以球囊内皮剥脱法建立血管损伤模型的基础上,用斑点杂交法测定损伤血管中血管紧张素原mRNA的表述状况。结果损伤血管组织中血管紧张素原mRNA的表达增高。结论局部RAS在损伤诱导的VSMC增殖中起重要作用。

【Abstract】 Purpose The expression of angiotensionogen(ANGT) gene mRNA was obserbed in order to further clarify thefunction that the local renin-angiotensin system(RAS) played in the vascular smooth muscle cell (VSMC) overgrowthinduced by injurying. Methods The expression of angiotensinogen gene in injury vessels was detected by dot blot. Re-sults The mRNA of angiotensinogen in injury vessels was higher than that in the norrnal vesse1s. ConcIusion LocalRAS played an imortant role in the VSMC overgrowth induced by injuring.

  • 【文献出处】 华北煤炭医学院学报 ,JOURNAL OF NORTH CHINA COAL MEDICAL COLLEGE , 编辑部邮箱 ,1999年06期
  • 【分类号】R392
  • 【下载频次】9
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