Objective The effect of perindopril on preventing pressure overload left ventricular hypertrophy and its mechanism was studied. Methods In the sixth week after operation ,mean arterious pressure (MAP) and ratio of left ventricular weight to body weight (LVW/BW)were examined. Total intestitial collagen volume (V(c)t)and average myocyte volume per nucleus (V(m)n)were measured and calculated by morphometry. Concentration of myocardial angiotensin Ⅱ(MAⅡ)were determined by radioimmunoassay. Results ...