【摘要】 目的　探索食管癌肉瘤的组织起源。方法　用免疫组织化学的方法对５例自管癌肉瘤的组织标本进行检测。结果　５例标本中的癌细胞Ｋｅｒａｔｉｎ均阳性，２例部分癌细胞、３例少数癌细胞Ｖｉｍｅｎｔｉｎ阳性。５例标本的肉瘤成分Ｖｉｍｅｎｔｉｎ均阳性，１例肉瘤成分Ｋｅｒａｔｉｎ阳性。５例标本Ｄｅｓｍｉｎ均阴性。组织学见癌与肉瘤成分有移行，５例中２例发生淋巴结转移，转移的成分１例为癌，１例为肉瘤，并分别为Ｋｅｒａｔｉｎ和Ｖｉｍｅｎｔｉｎ阳性。结论食管癌肉瘤可能起源于食管上皮的未分化储备细胞，部分向上皮分化形成癌，部分向间叶分化形成肉瘤。更多还原

【Abstract】 Objectie To explore the origin of the carcinosarcoma of the esophagus. Methods 5 cases of the esophageal carcinosarcoma were studied with the immunohistochemical and histological method. Result The carcinomatous cells were positive to keratin in all the cases and some carcinomatous cells in 2 of 5 cases and a few of carcinomatous cells in 3 of 5 were positive to vimentin. In all cases the sarcomatous elements were positive to vimentin and positive to keratin in 1 of 5 cases. AN cases were negative to desmin. The carcinomatous cell presented a transition to carcomatous cell in histology. 2 of 5 cases produced nodal metastases, one showed metastases of carcinomatous cells and another, sarcomatous elements. They were positive to Keratin and vimentin separately Conclusions The study suggested that carcinosarcoma of the esophagus originate in the pluripotent stem cells, and those cells undergo malignant degeneration and differentiation into separately carcinomatous and sarcomatous participants.更多还原