【摘要】 本文报道了α-苦瓜素和β苦瓜素分离纯化的工艺改进，测定了两种苦瓜素的理化性质。实验证明；两种苦瓜素对小鼠S－180实体瘤均具有显著的抑制作用，抑瘤率分别为71．2％和68．6％；两种苦瓜素对人胃癌NKM细胞株的DNA、RNA和蛋白质的合成亦均具有明显的抑制作用。同时证实α和β-苦瓜素对荷瘤小鼠和正常小鼠的免疫器官和免疫功能有毒副作用。更多还原

【Abstract】 In this paper, the improved isolation and purification methods of Q-momorcharin(α -mmc) and β - momorcharin(β-mmc) are reported, the antitumous effect of them is also studied. α-mmc and β-mmc both inhibit mice S-180 tumor (71.2% and 68.6%) and have significant inhibitory effect on DNA, RNA and proteins synthesis of NKM cells in vitrO. In addition, α-mmc and β-mmc can cause the weight of mice’s thymus and spleen light, inhibit the phagocytosis of neutrophil comparing with the control when injected intrapertioneally and T lymphocyte transformation stimulated by Con A in vivo. These results indicate that the antitumous mechanism of α-momorchrin and β momorcharin is the directed cytotoxicity.更多还原