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β-二酮异烟酰腙Ln(Ⅲ)配合物对生物自由基清除作用的研究

Elimination of Biological Free Radicals by Complexes of β-diketone Isonicotinylhydrazone with Ln(Ⅲ)

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【作者】 曾正志方建邓汝温

【Author】 Zeng Zhengzhi, Fang Jian, Deng Ruwen (College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China)

【机构】 兰州大学化学化工学院!甘肃兰州730000

【摘要】 合成了乙酰丙酮异烟酰腙(Hacac) ,乙酰乙酰二茂铁异烟酰腙(Hacfc) 以及它们与Ln( Ⅲ)的配合物Ln(acac)3 和Ln(acfc)3(Ln = La,Sm) 等化合物.用分光光度法和气相色谱法测定了它们对生物自由基(O- ·2 ) 和(OH·) 的抑制率.实验数据表明:Ln(acac)3 和Ln(acfc)3 对生物自由基的清除作用均高于其相应配体Hacac 和Hacfc,乙酰乙酰二茂铁异烟酰腙(Hacac) 和其配合物Ln(acfc)3高于Hacac 和Ln(acac)3 ,LnCl3 无抗氧化作用.这不仅说明配合物对生物自由基的清除表现出协同作用,而且还表明含有二茂铁基的配体Hacfc 和配合物Ln(acfc)3 对上述两种自由基均有更强的清除作用.

【Abstract】 The inhibition ratio of biological free radicals(O -· 2 and OH ·) by acetylacetone isonicotinylhydrazone(Hacac), acetoacetylferrocene isonicotinylhydrazone(Hacfc), LnCl 3 and their complexes Ln(acac) 3 and Ln(acfc) 3 was determined. Data of antioxidative test with spectrophotometric and gas chromatographic methods have shown that inhibition ratio of Ln(acac) 3 and Ln(acfc) 3 is higher than that of corresponding ligand Hacac and Hacfc, the antioxidative action of acetoacetylferrocene isonicotinylhydrazone Hacfc and Ln(acfc) 3 is higher than that of Hacac and Ln(acac) 3 has no antioxidative action. It will be seen from this that not only the combination of ligand and Ln(Ⅲ) produces synergistic action, but the ligand(Hacfc) and the complexes [Ln(acfc) 3] containing ferrocenyl group have very apparent elimination actions to the two free radicals mentioned above.

【基金】 甘肃省自然科学基金!(ZS991A21026N)
  • 【文献出处】 兰州大学学报 ,Journal of Lanzhou University , 编辑部邮箱 ,1999年04期
  • 【分类号】O641.4
  • 【被引频次】7
  • 【下载频次】98
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