【摘要】 ［目的］ 进一步了解接触平均浓度为１．０７ｍ ｇ／ｍ ３ 丙酮氰醇（Ａｃｅｔｏｎｅ Ｃｙａｎｏｈｙｄｒｉｎ，ＡＣ）的职业人群健康状况调查。［方法］ 通过职业性健康体检及尿硫氰酸盐（ＳＣＮ）等指标的实验室检查对４６ 名ＡＣ作业人员组和４６名不接触毒害因素人员组进行配对研究。［结果］ ①ＡＣ作业人群可有类神经症表现，且头昏、记忆力减退、食欲减退、恶心、腹胀痛等植物神经功能紊乱症状出现率较对照组高（Ｐ＜ ０．０５），但无阳性体征发现。②血清γ－ＧＴ、ＢＵＮ比对照组明显增高（Ｐ＜ ０．０５），而ＡＬＴ、ＡＬＰ、ＣＲＥ及尿ＳＣＮ 等未见明显改变。接触ＡＣ人群外周血淋巴细胞微核率与对照组相比，无明显升高，但是吸烟与ＡＣ遗传效应之间可能存在某种协同作用。［结论］ ＡＣ在目前浓度对接触人群的健康仍会发生一定影响，应重视对ＡＣ作业人群的健康监护。更多还原

【Abstract】 The effects on the health in workers exposed to low concentraction of acetone cyanohydrin (1.07mg/m 3 in average) were studied.The results showed that the rates of neurotic symptoms as dizziness,hypomnesia,anorexia,nausea and abdominal distension were significantly higher than those in the control group( P <0.05),and there were no positive signs found in medical examination.Comparing with the control group,the levels of serum γ GT,BUN significantly increased( P <0.05), but serum ALT,ALP,CRE and urine SCN showed no obvious changes.The rate of micronuclei in peripheral blood lymphocytes showed no significant change,but smoking might exert synergetic effects on micronucleus induction.更多还原