【摘要】 目的:研究苯丙醇胺在肠道中的吸收特点.方法:采用在体大鼠肠段回流实验,对苯丙醇胺的吸收特性从其主要影响因素pH值、吸收部位、药浓进行研究;含量测定采用酸性染料比色法,检测波长420nm,线性范围0～100μg/ml,r=0.9998.结果:回流液的pH值对吸收有显著影响,pH值在7.4～6.5之间呈特定吸收,在十二指肠及空肠上、中段的吸收明显大于下段和回肠;药浓在50～400μg/ml范围内无高浓度饱和现象,吸收系数基本保持不变.结论:苯丙醇胺在肠道中主要通过被动转运吸收.更多还原

【Abstract】 AIM: To study the feature of phenylpropanolamine absorption in intestine. METHODS: With regurgitation test in intestine segment of rat in vivo,studying the main in-fluence factors of pH value, absorption location and drug concentration of phenyl-propanolamine absorption. Drug content was determined with acid dye chromatometry, wave length 420 nm,linear rang 0-100 μg/ml,and r = 0. 999 8. RESURTS: The absorption was obviouly influenced by pH value of regurgitation fluid. The characteristic absorption occurred between pH7. 4-6. 5. The absorption content was obviously geater in the upper and medium parts than in the lower parts of deodenum and jejunum as well as in ileum. No saturation of high concentration was observed when drug concentration was in rang of 50-400 μg/ml. Ab-sorption quotient was kept unvaried basically. CONCLUSION: Phenylpropanolamine waspassively absorbed by transferring in intestine.更多还原