【摘要】 目的:探讨高血压病左心室肥厚(LVH)的药物逆转疗效与血压昼夜变化特征的关系.方法;44例LVH患者po依那普利10～20mg/d.用彩色心脏超声及动态血压监测观察其左室质量指数(LVMI)和昼夜血压分布节律的变化.结果:治疗24mo后.44例患者中19例LVMI恢复正常(组I),另25例仍高于正常(组Ⅱ).两组间LVM比较P<O.005.组I夜间血压下降更为显著.血压下降≥10%者治疗后LVMI显著低于夜间血压下降不足10%者(P<0.01).结论:高血压病LVH患者夜间血压下降幅度较大时依那普利逆转疗效可能较好.更多还原

【Abstract】 AIM: To study the effect of enapril on left ventricular hypertrophy (LVH) and its relationship with circadian blood pressure rhythm. METHODS: Enapril was administered to 44 patients with LVH, and colour echocardiagraphy and dynamic blood pressure monitor were used to evaluate the changes of lett ventricular mass index (LVM I ) and circadian characteristics of blood pressure. RESULTS: Among the 44 patients with LVH, 19 cases’ LVM I were reversed to nomal alter 24 mo treatment (Group I ), but LVM I in the others were still abnormal (Group I ) (P<0. 005, when comparing LVM I in 2 groups). The nocturnal dropping amplitudes in Group I were more larger than that in Group I . Compared to the patients those nocturnal dropping amplitudes less then 10%, LVM I s in the patients whose nocturnal dropping ≥ 10.% had decreased much obviously (P<0. 01). CONCLUSION: When the nocturnal blood pressure dropping amplitude≥10% , the patients with LVH may have better response to enapril treatment.更多还原