【摘要】 目的:比较半乳糖化重组人生长激素（Gal-rhGH）和重组人生长激素（rhGH）在小鼠体内的药物动力学特征.方法:用¹²⁵I标记Gal-rhGH和rhGH,通过小鼠尾静脉iv,测定血和肝中相对放射性随时间的变化,以3P87药物动力学程序进行模型拟合和参数求算.结果:¹²⁵I-rhGH-Gal在血中的相对放射性呈现双峰,其体内药物动力学特征与¹²⁵I-rhGH明显不同,进一步证实了Gal-rhGH的肝靶向性.结论:以放射性同位素标记示踪法成功比较了Gal-rhGH和rhGH的药物动力学特征.更多还原

【Abstract】 AIM : To compare the pharmacokinetics of galactosed recombinant human growth hormone （Gal-rhGh） and recombinant human growth hormone（rhGH）. METHODS: ¹²⁵I-Gal-rhGH and 125I -rhGH was labeled with chloramine-T method. They were given to mice by iv, respectively. The pharmacokinetics of them were investigated by computer program 3P87. RESULTS: The relative radioactivity of 125I -Gal-rhGH had double peaks in blood. There were significant different pharmacokinetic characters between 125I -Gal-rhGH and 1251-rhGH. CONCLUSION: The pharmacokinetic difference between 125I-Gal-rhGH and 125I -rhGH is successfully compared by isotope tracer labeling method.更多还原