【摘要】 目的：观察硝酸甘油（ＮＴＧ）耐受性对一氧化氮介导的血管舒张反应的影响。方法：实验白兔分为硝酸甘油（ＮＴＧ）耐受组（１０ 只）和正常对照组（ＮＣ）组（１０ 只）。在ＮＴＧ组兔的胸前置一ＮＴＧ贴剂，持续７２ ｈ。然后将兔处死，开胸取出胸主动脉，剪一主动脉环。此环连接张力换能器。用去甲肾上腺素预收缩后，依序观察ＮＴＧ、乙酰胆碱（ＡＣｈ）和硝普钠（ＳＮＰ）的舒张血管的反应性，并与ＮＣ组的舒张血管反应性对比。结果：ＮＴＧ耐受组兔离体动脉环对ＮＴＧ、ＡＣｈ 和ＳＮＰ的最大舒张程度均显著低于ＮＣ组（均Ｐ＜ ０．０１）。结论：ＮＴＧ耐受性可抑制一氧化氮介导的血管舒张反应更多还原

【Abstract】 Objective:The aim of the study was to observe the influnce of nitroglycerin tolerance to nitric oxide mediated vasodilation.Method:Rabbits in the study were divided into 2 groups:the nitroglyclin (NTG) tolenance group (10 rabbits) and the normal control (NC) group (10 rabbits).In NTG group,a NTG paste was pasted on the anterion chest wall of the rabbit for 72 hours.Then put the rabbit to death,opened its thorax,took its aortic out and cut out an aortic ring.The aortic ring was connected to a pressure transformer,the noradenaline was given to make the ring being in the precondition of contraction,then the vasodilative reactivities of the NTG,the acetylcholine,the aodimm nitroprusside were investigated successively,and there were compared with that of the contol group.Result:The relaxations of aorta rings to NTG,ACh and SNP in NTG tolerance group were significant lower than that observed in normal control group (P< 0.01 ).Conclusion:Nitroglycerin tolerance can inhibit nitric oxide mediatea vasodilation.更多还原