【摘要】 目的：研究急性心肌梗死（ＡＭＩ）时脂蛋白（ａ）〔ＬＰ（ａ）〕、血小板（ＰＬＴ）及蛋白激酶Ｃ（ＰＫＣ）的关系。方法：分别以高ＬＰ（ａ）血症的ＡＭＩ患者（３２例）及健康对照者（３２ 例）为对象，采用全自动血细胞分析仪检测其ＰＬＴ数量，双抗夹心ＥＬＩＳＡ单克隆抗体法测定ＬＰ（ａ）及液闪仪测定ＰＬＴ中ＰＫＣ底物４０ ｋｕ 蛋白磷酸化程度，对检测结果进行统计学分析。结果：ＡＭＩ组ＰＬＴ数目及４０ ｋｕ 蛋白磷酸化程度明显高于对照组（Ｐ＜ ０．０５），且磷酸化程度随着４０ ｋｕ 蛋白磷酸化反应时间的延长而增强（ Ｐ＜ ０．０５）。结论：ＬＰ（ａ）是ＡＭＩ的独立危险因素。高ＬＰ（ａ）血症的ＡＭＩ患者ＰＬＴ数目及ＰＬＴ中ＰＫＣ底物４０ ｋｕ 蛋白磷酸化程度均增高更多还原

【Abstract】 Objective:To study the reation of lipoprotein (a) 〔LP(a)〕、 platelet (PLT) and protein kinase C 〔PKC〕 in acute myocardial infarction (AMI).Method:The objects of this research composed of 2 groups,the group of AMI patient with high LP(a) (32 cases) and the group of healthy person(32 cases). Their level of LP(a), the amount of PLT and the level of cpm of each group were examined separately. The data obtained were analysed with statistics.Result:All data in three items mentioned above were higher in AMI group than that in control group.Conclusion:LP(a) is an independente risk factor for AMI. the number of PLT, and the level of 40 ku protein phosphorylated of PKC substracte in PLT were increased.更多还原