【摘要】 目的 :探讨苯那普利对高血压病 (EH)患者血浆内皮素 (ET)及一氧化氮 (NO)的影响。方法 :观察苯那普利 (5～ 2 0 mg,每日 1次口服 4周 )治疗的 30例 EH患者治疗前后血浆 ET、NO水平 ,并与 2 8例健康者血浆 ET、NO对照。结果 :EH患者 ET较对照组显著升高 (P <0 .0 1) ,NO显著降低 (P<0 .0 1)。经苯那普利治疗后 ,收缩压、舒张压都有显著性下降 (P<0 .0 1) ,ET显著下降(P <0 .0 1) ,NO显著升高 (P <0 .0 1)。结论 :苯那普利不仅有较好的降压作用 ,还能有效地恢复血浆 ET、NO的代谢水平更多还原

【Abstract】 Objective:To explore the effect of benazepril on serum endothelin (ET) and nitrogen oxide (NO) in patients with hypertension.Method:The patients were treated with benazepril 5～20 mg once daily for 4 weeks.The plasma levels of ET and NO were measured in 30 patients with essential hypertension before and after treatment,and there were also measured in 28 healthy controls.Result:The level of plasma ET in patients with hypertension was significantly higher (P< 0.01 ),but the plasma NO level of patients was lower than those of controls (P< 0.01 ).In patients with hypertension,the SBP and DBP were significantly lowered (P< 0.01 ),the level of plasma ET decreased (P< 0.01 ),but the plasma NO level increased (P< 0.01 ) after the treatment of benazepril.Conclusion:The treatment of benazepril plays an important rule not only in reducing the blood pressure but also in restoring normal plasma levels of ET and NO in patients with hypertension.更多还原