【摘要】 目的 :通过兔颈总动脉球囊损伤模型 ,观察血管紧张素 (Ang )的 AT1 受体阻滞剂Valsartan对损伤动脉内膜增生的影响 ,以寻找预防经皮腔内冠状动脉球囊成形术 (PTCA)后再狭窄的新药。方法 :设立假手术组、对照组和 Valsartan组。术前 2天至术后 2周 Valsartan组按 1 0 mg· kg-1 · d-1 给予 Valsartan,余二组不给药。观察术后 2周各组血浆内皮素水平、血管增殖指数及血管内膜厚度和管腔狭窄度。结果 :Valsartan组血浆内皮素、增殖指数均明显低于对照组和假手术组 (均 P <0 .0 1 ) ;血管内膜厚度及管腔狭窄度低于对照组 (分别 P <0 .0 1 ,P <0 .0 5)。结论 :Valsartan可抑制动脉损伤后内膜的增生。更多还原

【Abstract】 Objective:To study the effect of AngⅡ AT 1 receptor antagonist,valsartan,on the arterial intimal hyperplasia after ballon injury.Method:Eighteen rabbits were randomly divided into three groups:sham operation(S) group,control(Con)group and valsartan (V) group,each n=6.Valsartan was given to 6 rabbits (10 mg·kg -1 ·d -1 ,po)from 2 days before the right carotid arteries were injured by 3.6 F ballon catheter to 14 days after injury.The control group,6 rabbits underwent same ballon injury but no medicine was administered.Result:①Level of plasma ET 14 days after injury:V group was significantly lower than Con group,Con group was significantly higher than S group (P< 0.01 ,respectively).②Proliferation Index:Con group and V group were both higher than S group (P< 0.01 ,respectively),V group was significantly lower than Con group (P< 0.01 ).③Mean thickness and extent of lumen stenosis:Con group was significantly higher than S group (P< 0.01 ),V group was significantly lower than Con group (P< 0.01 ).Conclusion:Valsartan inhibits intimal thickening after ballon injury.更多还原