【摘要】 目的探讨粘附分子ＣＤ１１ａ、ＣＤ５４、ＣＤ６２在实验性变态反应性脑脊髓炎（ＥＡＥ）发生中的作用。方法采用Ｗｉｓｔａｒ大鼠建立ＥＡＥ动物模型，应用免疫荧光法检测正常大鼠及ＥＡＥ动物周围血和脑组织中Ｔ细胞亚群及ＣＤ１１ａ、ＣＤ５４、ＣＤ６２的表达。结果发病大鼠脑组织局灶周围有大量淋巴细胞浸润，主要为ＣＤ４Ｔ细胞；发病大鼠周围血淋巴细胞上及大鼠脑组织粘附分子的表达明显升高。结论粘附分子ＣＤ１１ａ、ＣＤ５４、ＣＤ６２的表达在ＥＡＥ的发生中起了重要作用更多还原

【Abstract】 Objective To study the role of adhesion molecules (CD11 a,CD54 and CD62) in onset of experimental allergic encephalomyelitis(EAE). Methods We established the experimental allergic encephalomyelitis(EAE) animal model with Wistar rats and exmained the subset of T cell and expression of adhesion molecules(ADMs) in EAE animals and normal ones with immunofluorescence method. Results Expression of adhesion molecules increased on lymphocytes not only in blood but also in brain.There were a lot of lymphocytes in EAE animal brain and most of these were CD4 T cell. Conclusion The expression of ADMs play an important role in the onset of EAE.更多还原