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聚合酶链反应法诊断结核病临床价值探讨
Study on diagnostic value of PCR in tuberculosis
【摘要】 目的 探讨 PCR法对结核病的诊断价值。方法 用 PCR法检测痰、纤支镜抽吸物、胸水和血液标本中结核杆菌 DNA。结果 PCR法敏感性为 2 1 9% ,特异性为 92 6% ,总的阳性预测值、阴性预测值和诊断效率分别为 64 6%、 65 9%和 65 8% ;不同标本敏感性有较大的差异。结论 PCR法诊断结核病的敏感性、特异性尚远不能完全满足临床的需要 ,需进一步完善和改进。
【Abstract】 Objective To study the diagnostic value of PCR in tuberculosis.Methods To detect mycobacterium tuberculosis DNA by PCR tecnique in 901 specimens,including sputum,bronchial lavage fluid,pleural effusion and blood.Results The sensitivity and specificity of PCR was 21.9% and 92.6%,respectively.Total positive predictive value,negative predictive value and diagnosis efficiency was 64.6%,65.9%and65.8%,respectively.Conclusion PCR techinque may be useful on diagnosis of tuberculosis,but at present the sensitivity and specificity are too low to meet clinical need.
- 【文献出处】 临床内科杂志 ,JOURNAL OF CLINICAL INTERNAL MEDICINE , 编辑部邮箱 ,1999年05期
- 【分类号】R52
- 【下载频次】30