【摘要】 为探讨ＥＴ－１与口腔粘膜下纤维性变（ＯＳＦ）的关系，应用免疫组化染色和图像分析技术，检测了ＯＳＦ３０例、正常口腔粘膜（ＮＯＲ）１０例组织中ＥＴ－１的定位分布和含量。结果显示：①ＯＳＦ组织中ＥＴ－１有异常表达，其免疫阳性物质主要分布于上皮棘细胞、基底细胞，间质成纤维细胞、血管内皮细胞及平滑肌细胞的胞浆胞膜上；②ＥＴ－１在ＯＳＦ组织表达的阳性率及相对含量均显著高于ＮＯＲ（Ｐ＜０．０１）；③ＯＳＦ各期ＥＴ－１相对含量存在差别，其中早、中期上皮细胞ＥＴ－１相对含量显著高于晚期（Ｐ＜０．０５）。由此提示，ＥＴ－１可能参与了ＯＳＦ的纤维化过程更多还原

【Abstract】 WT5”BZ〗In order to urderstand whether ET 1 is involved in the pathology of oral submucous fibrosis (OSF),a sensitive immuno histochemical and morphometric technique was adopted in the examination of the localization and content of ET 1 in oral mucosa from 30 patients with OSF, 10 normal oral mucosa. The results showed that:(1) Overexpression of ET 1 showed in mucosa from OSF, the immunostains for ET 1 were prominent within the cytoplasm and on the cell membrane of spinocells, basiocells,fibroblasts, vascular endothelial and smooth muscle cells.(2) The proportion of ET 1 positive cells and the cellular content of ET 1 in OSF was all significantly higher than that in normal control ( P <0.01);(3) Difference exists between early, moderate and advanced stages OSF, while the cell contents of ET 1 in early and moderate stages were significantly higher than that in advanced stage in epithelium ( P <0.05). ET 1 conld play a role in the fibrogenic process of OSF.更多还原