【摘要】 目的　观察研究顺铂—白蛋白微球 ( CDDP-AMS)经舌动脉导向治疗舌癌的机理及微球的体内过程。方法　利用平均 5 6 .3μm的顺铂—白蛋白微球分别对 7例晚期舌癌病人行舌动脉灌注术 ,分别于立即、1周、2周、3周、4周、5周、6周、时行联合根治术 ,对术后标本进行显微及超微结构观察。结果　顺铂—白蛋白微球舌动脉栓塞导向治疗舌癌的显微和超显微结构改变主要表现为肿瘤细胞的程序死亡和缺血性坏死、变性改变 ,4周时基本可杀灭全部癌细胞 ;微球在体内逐渐水解 ,6周后全部消失。结论　顺铂—白蛋白微球舌动脉栓塞导向治疗舌部鳞癌的机理 :顺铂局部高浓度、长时间的杀瘤作用和微球栓塞后肿瘤缺血坏死的协同作用结果 ,是一种很好的治疗舌部肿瘤的方法更多还原

【Abstract】 Objective To observe and study the mechanism cisplatin loaded albumin microspheres infusion through lingual artery in treating carcinoma of tongue and the in vivo process of microspheres. Methods Perform lingual arterial infusion on 7 patients with terminal carcinoma of tongue by using cisplatin loaded albumin microspheres 56.3μm in diameter, respectively exercise combined treatment at once, 1,2,3,4,5,6weeks, then micro and supermicro structure observe the specimen after the operation.Result Micro and supermicro structure change of arterial embolism with cisplatin loaded albumin microspheres in treating squamous cell carcinoma of tongue is mainly embodied by programmed cell death, ischemic necrosis and degeneration change. Almost all carcinoma cells can be killed at the fourth week. Microspheres are hydrolysed graduallyin the body and vanish completely in 6 weeks.Conclusion The mechanism of arterial embolism with cisplatin loaded albumin microspheres in treating squamous cell carcinoma of tongue is the combined work of albumin’s cytotoxic and time lasting effect to kill the carcinoma cell and ischemic necrosis of tumor after microemblism makes it a good method to treat lingual tumor.更多还原