【摘要】 通过结扎大鼠双侧颈总动脉建立脑缺血再灌注损伤动物模型，采用放射免疫分析技术检测其体内的内皮素（ET）水平，来研究甘糖酯（PGMS）和尼莫地平（NIM）对缺血再灌注损伤大鼠脑实质的影响．实验结果表明，PGMS和NIM都能降低缺血再灌注损伤大鼠血浆及脑组织中ET的含量，保护缺血引起的神经元损伤，为临床治疗脑血管疾病提供了新的思路。更多还原

【Abstract】 The effects of propylene glycol mannate sulfate(PGMS) and nimodipine (NIM) on the brain tissue were studied in rat model with ischemia repeffosion brain injury by the application of ET radioimmunoassay The rcsults show that PGMS and NIM protect the ischemic neurons in the rats by decreasing the ET lcvel in the plasma and brain tissue suggesting PGMS plays a role in the prevention and treatment of cerebrovascular diseases.更多还原