【摘要】 目的：探讨涎腺肿瘤细胞的形态分化、组织发生及其异质性。方法：采用光镜、免疫组化技术对８例腺淋巴瘤、３例嗜酸性腺瘤、１２例多形性腺瘤及２例上皮－肌上皮癌进行研究，同时观察了５６例胚胎颌下腺组织作为对照。结果：多形性腺癌中导管样结构系肿瘤性闰管结构和肿瘤性分泌管结构；腺淋巴瘤和嗜酸性腺瘤中导管结构系肿瘤性分泌管结构；上皮－肌上皮癌中导管结构系肿瘤性闰管结构；涎腺肿瘤组织结构及抗原表达复杂多样，与人胚涎腺发生过程中结构及抗原表达有相似之处。结论：涎腺肿瘤的复杂性系致瘤因素作用于不同干细胞或同一干细胞不同分化阶段所致。更多还原

【Abstract】 Objective: To investigate cell differentiation, histogenesis and heterogenety of salivary gland neoplasm. Methods: 12 cases of pleomorphic adenoma(PA), 8 cases of adenolymphoma(AL), 3 cases of oxypyilic adenoma(OA) and 2 cases of epithelial - myoepithelial carcinoma(EMC) were studied by light microscope and immunohistochemistry, 56 cases of human embryo submandibulr gland as control. Results: The ductal structure of PA is similar to intercalated duct and secretory duct, the ductal structure of AL and OA is similar to secretory duct, the ductal structure of EMC is similar to intercalated duct. The histostructures and antigen expression of these neoplasms were rather complicated and antigen expression changes of these neoplasms seemed very similar to those of the developing embryonic submandibular glands. Conclusion: Salivary gland neoplasm might have originated from pluripotential reserve cells.更多还原