【摘要】 采用链脲佐菌素（ＳＴＺ）腹腔注射建立糖尿病大鼠模型，观察中药复方止消通脉宁对其肾小球形态学的影响。结果表明：与正常对照组相比，各组糖尿病大鼠肾小球毛细血管基底膜厚度（ＧＢＭＷ）、系膜区平均面积［Ａ（Ｍ）］、肾小球平均截面积［Ａ（Ｇ）］、肾小球直径［Ｄ（Ｇ）］和肾小球体积［Ｖ（Ｇ）］均显著增加，其中模型组最为明显，西药组次之，中药组最轻。控制肾脏肥大、减轻ＧＢＭ增厚以及抑制系膜增生，是止消通脉宁治疗糖尿病肾病的主要作用机制。更多还原

【Abstract】 A diabetes rat model was establisbed by intraperitoneal injection of streptozotocin. Observe the effects of Zhixiaotongmaining on the glomerular morphologic changes. The results show that: Compared to the normal control group, there are markedly increase of glomerular basement membrane width (GBMW), average mesentery area , average glomeruluar sectional area, , glomerular diameter and volume in the deabetes group, among which the model group is most remarkable, the western medicine group is second to it and the Chinese medicine group is the lest remarkable. So controlling nephrohypertrophy, modifying GBM widening and inhibiting mesentery proliferation are the main mechanism of action.更多还原