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绝经后2型糖尿病患者雌二醇受体的变化
The Change of Estradiol Receptor Level in Postmenopausal NIDDM Patients
【摘要】 目的:探讨雌二醇受体(ER)数目与绝经后2型糖尿病的关系。方法:随机选测绝经后2型糖尿病患者30例和60例正常妇女(绝经前后各30例)。采用放射配体法检测外周血白细胞ER含量;采用放射免疫法检测血浆雌二醇(E2)浓度。结果:绝经后2型糖尿病组白细胞ER及血浆E2不仅非常显著低于正常绝经前组(P<0.001),且较正常绝经后组也明显下降(P<0.01)。结论:绝经后2型糖尿病的发病可能与雌二醇及ER的降低有关。
【Abstract】 Objective:To explore the changes of estradiol receptor (ER) numbers and its relation with postmenopausal non insulin dependant diabetes mellitus(NIDDM).Methods:ER on blood white cells were measured by radioligand binding assay in women divided to 3 groups:group A postmenopousal with NIDDM (n=30); group B normal postmenopausal(n=30);group C normal premenopausal (n=30). Plasma estradiol(E2) conceutration with radioimmuoassay were also measured.Results:The levels of E2 and ER in group A were all lower remarkly than those of group C(P<0.001) and group B(P<0.01). Conclusion:The pathogenesis of postmenopausal NIDDM may be related with the reductions of E2 and ER.
【Key words】 Diabetes mellitus Non insulin dependent Receptor Estradiol/blood Climacteric;
- 【文献出处】 江西医药 ,JIANGXI MEDICAL JOURNAL , 编辑部邮箱 ,1999年01期
- 【分类号】R587.102
- 【被引频次】5
- 【下载频次】43