【摘要】 目的 了解在应用抗精神病药物治疗精神分裂症过程中出现的强迫症状,是否为药物所致。方法 对上海市精神卫生中心分部某一病区所有正在应用抗精神病药物治疗的住院精神分裂症病人,以Y-BOCS及MSCPOR量表评定。凡发现有强迫症状者,予以减药直至停药,观察强迫症状的变化,以期证实其与抗精神病药物的关系。结果 共调查430名,发现确实系抗精神病药所致强迫症状者4例,均为服用氯氮平者,占服氯氮平病例总数1.41％。结论 氯氮平可产生强迫症状,在临床应用时应予注意。更多还原

【Abstract】 Objective: To find out whether obsessive-compulsive symt toms emergent during autipsychotic medication were induced by the drugs. Method: Yale-Brown ar 1 MSCPOR scales were used to evaluate the obsessive-compulsive symptoms in schizophrenic inpath its taking antipsychotic drugs. For the patients with obsessive-compulsive symptoms, the drugs v ire tapered down and withdrawn, in order to see if the symptoms would disapper, and then to verify the relationships between the obsessive-compulsive sumptoms and the use of antipsychotics. Resluts: Of 430 patients, 4 cases were identified with obsessive-compulsive symptoms which were attributed to the use of clozapine, accounting for 1.41% of all patients taking it. Conclusion: Clozapine may induce obsessive-compulsive symptoms and attention should be paid to this risk.更多还原