【摘要】 目的 :探讨睫状神经营养因子对应激引起海马 CA3区神经元损害的作用。方法 :采用 Bielschowsky- Gros-Lawrentjew染色法和常规透射电镜技术 ,观察急性和慢性足底电击大鼠的海马 CA3区神经元形态的变化 ,及双侧海马注射睫状神经营养因子对其影响。结果 :急性应激大鼠海马神经元形态无明显变化 :慢性应激大鼠海马神经元出现明显的损伤性形态变化 ;睫状神经营养因子对正常大鼠和急性应激大鼠的海马神经元形态无明显作用 ,但可显著减轻海马神经元损伤程度。结论 :睫状神经营养因子可能通过保护海马 CA3区神经元从而改善慢性应激大鼠的行为障碍更多还原

【Abstract】 Objective:To investigate the effects of ciliary neurotrophic factor(CNTF) on neural damage in hippocampal CA3 induced by stress. Methods: The changes of morphology of hippocampal neurons during acute or chronic footshock stress in rats, and the effects of CNTF administrated into bilateral hippocampus on the changes were observed by Nissl staining, Bielschowsky Gros Lawrentjew staining and electron microscopy. Results: The morphology of CA3 neurons in the hippocampus was not changed during acute stress in rats but changed during chronic stress. CNTF administrated into bilateral hippocampus did not effect the morphology of CA3 neurons in the control and acute stressful rats, but significantly reduced CA3 neuronal damage induced by chronic stress. Conclusion: CNTF can protect CA3 neurons from damage induced by chronic stress.更多还原