【摘要】 目的 :研究大鼠杏仁中央核内 P物质标记神经元的分布和形态的增龄性变化。方法 :应用免疫细胞化学结合图像定量分析法研究 3月龄 ,9月龄和 2 4月龄大鼠杏仁中央核内 P物质标记神经元的变化。结果 :P物质标记神经元主要位于杏仁中央核的内侧亚区和腹侧亚区 ,随月龄的增加 ,P物质标记神经元出现明显的细胞数量减少 ,细胞面积增大 ,且 2 4月龄大鼠还出现细胞突起增多 ,伸长 ,弯曲等明显的形态改变。结论 :大鼠杏仁中央核内 P物质标记神经元的形态有明显的年龄变化更多还原

【Abstract】 The immunohistochemical method and image quantitative analysis were used in this study. Eighteen male Wistar rats were divided into three groups: 3 month, 9 month and 24 month group. The aging changes of substance P(SP) in the central nucleus of the amygdala were observed. The findings were as follows: SP neurons were mainly localized in the medial subdivision and the ventral subdivision of the central nucleus of amygdala; the number of SP nerons decreased sigmificantly with the increasing of age(P<0.05), but the average area of SP neurons increased markedly(P<0.05). In twenty four month group, the processes became longer and winding. The results showed that SP neurons in the central nucleus of amygdala had marked changes with the increasing of age.更多还原