【摘要】 目的 :研究大鼠脑内白细胞介素 1I型受体 m RNA表达神经元的分布。材料和方法 :以 35S标记的 IL- 1Rt Ic DNA作为探针 ,采用原位杂交技术检测大鼠脑内 IL- 1Rt I m RNA表达神经元分布广泛而又不均匀。根据表达IL- 1Rt I m RNA神经元的密度变化 ,大鼠脑可分为四种密度区 :非常高、高、中等、低密度区。结论 :提示脑内白细胞介素 1通过其 I型受体介导而发挥作用更多还原

【Abstract】 Objective:To study the distribution of neurons expressing IL 1 RtI mRNA in rat brain. Materials and Methods: IL 1 RtI cDNA was used as a probe to evaluate the expression of IL 1 RtI mRNA in Wistar rat brain by in situ hybridization. Results: The neurons expressing IL 1 RtI mRNA distributed distinctively and widespread in rat brain. According to the density of the neurons containing IL 1 RtI mRNA, the rat brain could be divided into four degrees: very high, high, median, and low density areas. Conclusion: The results suggest that the function of IL 1 may be mediated by the IL 1 type I receptor in the brain.更多还原