【摘要】 目的　探讨层粘连蛋白和纤维粘连蛋白在绒毛发生、发育，胎盘的形成、构建过程中的作用。方法　采用免疫组织化学方法观察层粘连蛋白和纤维粘连蛋白在正常人胚早期绒毛膜和蜕膜组织中的分布。结果　层粘连蛋白在正常绒毛上皮基膜、毛细血管内皮基膜、蜕膜细胞及细胞间质内呈阳性表达。纤维粘连蛋白在绒毛间质、毛细血管内皮基膜、蜕膜细胞及细胞间质内呈阳性表达。结论　层粘连蛋白和纤维粘连蛋白是滋养细胞对子宫内膜粘附和侵蚀的重要生物学因素，在绒毛的发生、发育，胎盘形成和构建过程中均起重要作用。更多还原

【Abstract】 Objective To explore the effects of LN and FN in the process of development of villi, and formation of placenta.Methods Immunohistochmical method was used to observe the distribution of LN and FN in normal chorion and decidual tissue during early pregnancy.Result LN and FN were positive stained in normal human chorion. LN was detected in the basement mebrane of placental villi and blood vessels, and decidual tissue, and FN was detected in the matrices of villi, basement membrane of blood vessels and decidual tissue.Conclusion LN and FN are important biofactors for adhesion and invasion of trophoblasts. They play an important role in the process of development of chorion villi and formation of placenta.更多还原