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不同剂量消心痛静脉滴注治疗急性心肌梗塞的疗效观察
Healing Effect of Nitrate Esters on Acute Myocardial Infarction by Intravenous Drip of Different Dosage
【摘要】 目的:探讨消心痛注射液治疗急性心肌梗塞(AMI)的剂量与疗效的关系。方法:对已确诊的AMI患者45例随机分为3组,分别用消心痛(Isoket)20、40、60mg/d静脉间歇(每天间歇6~8h的无药期)或持续(24h持续)滴注5~7d,观察患者临床症状的改善情况,心电图变化、血清酶学的改变及死亡率。结果:疗效与上述药物剂量及用药方式(间歇或持续)无显著相关性(P>005)。结论:为了预防硝酸酯类的耐药性及病人依赖性的发生,同时节省药费开支,以20~40mg/d且间歇静滴为宜。
【Abstract】 Aim: To study the relationship between dosage of Nitrate esters and healing effect on Acute myocardial infarction(AMI).Methods: Forty-five AMI patients were randomly divided into three groups and were treated by Isosorbite dinitrate, which were given 20 mg/d and 40 mg/d in 6 to 8 hours respectively and 60 mg/d was given 24 hours continuously for 5 to 7 days. Improving of clinical symptoms. ECG, myocardial enzyme and martality were observed.Results: The healing effect had no relation to dosage of Isosorbite dinitrate nor to the method of giving(interval or continua, P >0 05).Conclusions: Probably Isosorbite dinitrate given 20~40 mg/d every 6 to 8 hours a day by intravenous drip to AMI pationts would prevent drug depence and drug fast and also reduce patients cost.
【Key words】 acute myocardial infarction; nitrate esters; ECG; myocardial enzyme;
- 【文献出处】 暨南大学学报(自然科学与医学版) ,JOURNAL OF JINAN UNIVERSITY(NATURAL SCIENCE & MEDICINE EDITION) , 编辑部邮箱 ,1999年02期
- 【分类号】R542.22
- 【被引频次】1
- 【下载频次】12