【摘要】 目的：探讨消心痛注射液治疗急性心肌梗塞（ＡＭＩ）的剂量与疗效的关系。方法：对已确诊的ＡＭＩ患者４５例随机分为３组，分别用消心痛（Ｉｓｏｋｅｔ）２０、４０、６０ｍｇ／ｄ静脉间歇（每天间歇６～８ｈ的无药期）或持续（２４ｈ持续）滴注５～７ｄ，观察患者临床症状的改善情况，心电图变化、血清酶学的改变及死亡率。结果：疗效与上述药物剂量及用药方式（间歇或持续）无显著相关性（Ｐ＞００５）。结论：为了预防硝酸酯类的耐药性及病人依赖性的发生，同时节省药费开支，以２０～４０ｍｇ／ｄ且间歇静滴为宜。更多还原

【Abstract】 Aim: To study the relationship between dosage of Nitrate esters and healing effect on Acute myocardial infarction(AMI).Methods: Forty-five AMI patients were randomly divided into three groups and were treated by Isosorbite dinitrate, which were given 20 mg/d and 40 mg/d in 6 to 8 hours respectively and 60 mg/d was given 24 hours continuously for 5 to 7 days. Improving of clinical symptoms. ECG, myocardial enzyme and martality were observed.Results: The healing effect had no relation to dosage of Isosorbite dinitrate nor to the method of giving(interval or continua, P >0 05).Conclusions: Probably Isosorbite dinitrate given 20～40 mg/d every 6 to 8 hours a day by intravenous drip to AMI pationts would prevent drug depence and drug fast and also reduce patients cost.更多还原