【摘要】 选用甲壳糖为原材料，在其主链上引入－ Ｃ Ｏ Ｏ Ｈ 和－ Ｓ Ｏ３ Ｈ 两种基团制备成类肝素化合物研究反应过程中羧甲基和磺酸基取代度的影响因素及不同取代位置、不同取代度的化合物复钙时间和溶血率结果表明，甲壳糖类肝素化合物的抗凝血性能是由甲壳糖主链上引入的－ Ｃ Ｏ Ｏ Ｈ 和－ Ｓ Ｏ３ Ｈ 两种基团的协同效应产生的，血液相溶性的优劣主要取决于－ Ｃ Ｏ Ｏ Ｈ 和－ Ｓ Ｏ３ Ｈ 两者的比例 Ｎ－ Ｃ Ｍ， Ｏ－ Ｓ Ｏ３ Ｈ 甲壳糖，当 Ｎ－ 羧甲基取代度为０５８５ ， Ｏ－ 磺酸基取代度为０５９３ 时其抗凝血性能最优，而 Ｎ－ Ｓ Ｏ３ Ｈ， Ｏ－ Ｃ Ｍ 甲壳糖，当 Ｎ－ 磺酸基取代度为０６８９ ， Ｏ－ 羟甲基取代度为０５９３ 时，其血液相溶性最佳更多还原

【Abstract】 Heparin-like compounds were prepared by introducing-COOH and-SO 3H into chitosan. Influence factors for the degree of substitution of -COOH and -SO 3H in the course of reaction were discussed. Comparasions of recalciffication times and degree of hemolysis of these compounds, with reference to the position and degree of subtitution of each individual group. Results showed that anticogulant properties of heparin-like compounds of chitosan were simultaneously affected by both-COOH and-SO 3H in the main chains of chitosan. N-CM, O-SO 3H chitosan had good anticogulant property when the degree of substitution of N-carboxymethy was 0 585 and that of O-sulfated group was 0 417; N-SO 3H, O-CM chitosan had good blood compatibility when the degree of substitution of N-sulfated group was 0 689 and that of O-carboxymethy was 0 593.更多还原