【摘要】 目的 :探讨细胞因子在急性胰腺炎中的变化及其临床意义。方法 :检测了 42例急性胰腺炎患者血清肿瘤坏死因子 (TNF)、白细胞介素 6 (IL 6 )及C 反应蛋白 (CRP)。结果 :所有胰腺炎患者在入院第 1、 4天 ,血清肿瘤坏死因子、白细胞介素 6均明显升高 ,尤其是重型患者 ,升高更为明显。CRP在入院第 1天无明显升高 ,第 4天时升高显著。结论 :肿瘤坏死因子α、白细胞介素 6、C 反应蛋白等三种细胞因子参与了急性胰腺炎的发病过程 ,其测定可作为急性胰腺炎诊断及判断预后的指标更多还原

【Abstract】 Objective:To study the clinical significance of serum cytokines in patients with acute pancreatitis(AP).Methods:Tumor necrosis factor(TNF α),interleukin 6(IL 6),and C reactive protein(CRP) levels were determined in 42 patients with AP.Results:On the 1st and 4th days after admission all patients with AP and especialy in the severe cases,TNF α、IL 6 levels were elevated significantly than that in normal controls,but the level of C reactive protein did not change on the lst day,It was elevated only following the increasment of TNF α、IL 6 on the 4th day.Conclusion:Cytokines are involved in the pathogenesis of AP.Measurement of serum TNF α、IL 6、CRP levels may be taken as useful markers to diagnose and the prognosis of AP.更多还原