【摘要】 为探索米非司酮用于紧急事后避孕的最低有效剂量,接纳无保护房事后120小时内要求紧急服药避孕者共150例,随机分成三组,分别为600mg组49例;50mg组51例及10mg组50例,均为一次服药,比较避孕有效率,副反应发生率及对下次月经来潮的影响。结果仅10mg组有1例妊娠,按Dixon法计算出三组相应的避孕有效率:600mg组、50mg组均为100％,10mg组为75.8％。副反应轻微,月经延迟发生率在7天以上者,三组分别为12.3％、11.7％及8.2％。研究结果证明低剂量米非司酮10mg和50mg用作紧急事后避孕和高剂量600mg同样有效。更多还原

【Abstract】 A total of 150 Women requesting emergency contraception within 120hrs after unprotected intercourse were randomly allocated to three groups: ①group l(n = 49), 600mg; ②group 2, (n = 51), 50mg and ③ group 3, (n = 50), 10mg. The effectiveness, side effects and cycle disturbance were compared.Results showed only one pregnancy occurred in group 3. The Contraceptive effective rates were 100 % in both group 1 and 2, and 75.8% in group 3, according to Dixon’s method. Side effects were slight.Menstruation postponed over 7 days was 12.3% in group 1; 11.7% in group 2 and 8.2% in group 3.Conclusion: Low dose mifepristone 50mg and lOmg were all as effective as the high dose 600mg in e-mergency postcoital contraception.更多还原