【摘要】 目的　验证可乐定的抗溃疡性结肠炎（ＵＣ） 作用，并为ＵＣ 患者提供一味良好的治疗药物；方法　选择ＵＣ患者１６０ 例，随机分成治疗组和对照组，两组均定时检测结肠粘膜病理改变及临床症状变化，数据记入ＵＣ 追踪治疗记录表作Ｘ２ 检验；结果　可乐定组总有效率为９１ ．２５ ％ ，ＳＡＳＰ 组总有效率为８８ ．７５ ％ ，两组无显著差异（ Ｐ＞ ０ ．０５） ，但可乐定组溃疡愈合率、腹痛缓解率及里急后重消除率均优于ＳＡＳＰ 组（ Ｐ＜ ０ ．０５） ；结论　可乐定确有抗ＵＣ作用，可广泛推广应用，一般应从小剂量开始。更多还原

【Abstract】 Objective To verify the anti-UC effect of Clonidine and provide the patients with UC with a good medicine.Methods There were 160 patients with UC who were divided into two groups:the therapeutic group(clonidine,0.3mg tid 6 weeks in all)and the control group(SASP,1.5,tid 6 weeks in all).The pathologic changes and the change of clinical symptoms were tested regularly in two groups. The data were recorded in the recording list and the X 2 test was made. Results The total efficiency in the clonidine group was 91.25%,and in the SASP group 88.75%.There was no significant difference(P>0.05) between the two groups.But the ulcerative union rate,the abdominal pain remission rate and the tenesmic eliminatiou ratio in the clonidine group were all superior to those in the SASP group.Conclusion Clonidine has an anti-UC effect indeed. It is worth disseminating after the dose is suitable and has important social benefits.更多还原