【摘要】 采用电子自旋共振（ＥＳＲ）法和自旋捕获技术研究了中药黄芩中四种主要黄酮（黄芩素、黄芩甙、汉黄芩素和汉黄芩甙）的自由基清除作用及可能的作用机理．结果表明黄芩素和黄芩甙对羟自由基、超氧阴离子自由基、烷过氧自由基及ＤＰＰＨ自由基有较强的清除作用，而汉黄芩素和汉黄芩甙在测定浓度范围内对上述自由基作用较弱或无明显的清除作用．黄芩素和黄芩甙的自由基清除活性大大高于汉黄芩素和汉黄芩甙的原因是其结构中含有邻二酚结构更多还原

【Abstract】 Free radical scavenging effects of the four main flavonoids in scutellaria baicalensis georgi,baicalein,baicalin,wogonin and wogonoside were studied by using electron spin resonance (ESR) and spin trapping techniques. The results showed that baicalein and baicalin scavenged hydroxyl radical,superoxide anion radical,alkyl radical and DPPH radical effectively while wogonin and wogonoside did subtly or ineffectively within the tested concentrations. The free radical scavenging of the four flavonoids could be described in the order of baicalein>baicalinwogonin>wogonoside. Baicalein and baicalin could scavenge free radical more effetively than the other two flavonoids due to the ortho dihydroxyls structure in their molecules.更多还原