【摘要】 通过向PBMC中加入IFN－γ、IL-2、IL－1α及抗CD3单克隆抗体，诱导出高效免疫活性细胞团子激活的杀伤细胞（Cytokine－inducedkillercells，CIK），并建立了小鼠克洛氏肉瘤(S₁₈₀)荷瘤动物模型，证实CIK过继免疫疗法具有显著的抗肿瘤作用，其抑瘤率可达78％；并同时以LAK细胞作为对照，LAK组的抑瘤率为对33.70%，明显低于CIK组13．30％（p＜O．05）。更多还原

【Abstract】 In this paper, the highly efficient cytolytic effector cells termed CIK （cytokine - inducedkiller） cells were generated by culturing PBMC in the presence of IFN-γ IL-2 IL-1α and McAb againstCD3 .The mice bearing S₁₈₀ sarcoma was used to evaluate the anti-tumor effects of CIK and LAK cells invivo .The results showed that CIK cells had significanily anti-tumor effects （the median inhibitory rate was78% ）. It suggested that CIK therapy was correlated with inducing the proliferation of spleen T cells otherthan the NK cytolytic activity.更多还原