【摘要】 为评价比时间常数（Ｓτ）和Ｆ－Ｖ曲线形状在检查吸烟者小气道功能中的意义，对１１６例被动和轻、重度主动吸烟者进行了常规肺通气功能、Ｓτ和Ｆ－Ｖ曲线形状的研究。常规肺通气功能和Ｆ－Ｖ曲线形状用常规法测定。Ｓτ用公式Ｓτ＝１／·Ｖ计算。结果表明：凸型Ｆ－Ｖ曲线分布随吸烟程度加重而上升，·Ｖ５０、·Ｖ２５则下降及Ｓτ５０、Ｓτ２５延长在凸型与重度吸烟组一致。Ｓτ５０、Ｓτ２５延长的范围在凸型与重度吸烟组都是预计值的１２０％～１３０％，表明小气道功能有轻度障碍。与以前所测ＣＯＰＤ患者比较，其Ｓτ７５、Ｓτ５０、Ｓτ２５延长均加剧，表明大小气道都遭累及。故凸型、Ｓτ５０和Ｓτ２５延长、·Ｖ５０和·Ｖ２５下降都是检查小气道功能的敏感指标。可推荐临床应用参考。更多还原

【Abstract】 To evaluate the clinical significance of the specific time constant (S) and FV curve configuration in testing small airway functions for smokers, routine ventilatory functions, S and FV curve configuration were studied in 116 passive and light, heavy active smokers. Routine ventilatory functions and FV curve configuration were determined with routine method. S were calculated from S=1/ V .The results showed that the distribution of convex type rose with the degree of smoking, and the decrease of V 50, V 25 and elongation of S50,S25 in convex type were just consistent with heavy smokers. The range of elongation of S50 and S25 was 120%130% of predicted value in both heavy smokers and convex type. These showed there were slight disturbances in functions of small airways. Compared with COPD patients previously measured, their S75,S50,S25 all prolongated to higher degree and meant both large and small airways were affected. Therefore, the convex type, elongation of S50 and S25, and decrease of V 50 Configuration of FV curvePartial mean transit timeSmokingChronic obstructive pulmonary diseaseand V 25 were sensitive indices for detecting small airway functions. They can be recommended for clinical application.更多还原