【摘要】 为评价部分平均通过时间（ＭＴＴｐ）和Ｆ－Ｖ曲线形状对检查吸烟者小气道功能的临床意义，作者对１１６例被动和轻、重度主动吸烟者进行了常规肺通气功能、ＭＴＴｐ和Ｆ－Ｖ曲线形状的探讨。常规肺通气功能和Ｆ－Ｖ曲线形状用常规法测定。ＭＴＴｐ用“简易计算法”公式计算。结果显示凸型Ｆ－Ｖ曲线的分布随吸烟程度而上升。·Ｖ５０、·Ｖ２５下降及ＭＴＴ４５％～５５％、ＭＴＴ７０％～８０％延长在凸型与重度吸烟组一致。ＭＴＴ４５％～５５％与ＭＴＴ７０％～８０％延长的范围在两者都是预计值的１１０％～１２０％，表明小气道功能已有轻度障碍。因而凸型Ｆ－Ｖ曲线、ＭＴＴ４５％～５５％及ＭＴＴ７０％～８０％延长、·Ｖ５０、·Ｖ２５下降都是检查小气道功能的敏感指标。用“简易计算法”计算ＭＴＴｐ简便准确，宜于临床推广应用更多还原

【Abstract】 To assess the clinical significance of partial mean transit time(MTT p) and F V curve configuration for testing small airway functions in smokers, routine ventilatory functions, MTT p and F V curve configuration were studied in 116 passive and active light, heavy smokers. Routine ventilatory functions and F V curve configuration were determined with routine methods. MTT p were calculated with “convenient calculation”. The results showed that the distribution of convex type of F V curve rose with the degree of smoking. The decrease of ·V 50 , ·V 25 and prologation of MTT 45% 55% ,MTT 70% 80% in convex type were just correspondent with heavy smokers. The range of prolongation of MTT 45% 55% and MTT 70%～80% was 110% 120% of predicted value both in heavy smokers and convex type. These showed there were light disturbances in small airways. Therefore, the convex type, the prolongation of MTT 45%～55% and MTT 70% 80% , and the decrease of ·V 50 and ·V 25 should all be used as sensitive indices for testing small airway functions. The value of MTT p calculated with “convenient calculation” is accurate and easy to do so the method is appropriate for clinical application.更多还原