【摘要】 为探讨呼吸道病毒感染或携带与激素敏感型单纯性肾病（ Ｓ Ｒ Ｓ Ｎ Ｓ）病情变化的相关性及其在该病触发机理中的作用，对１４例 Ｓ Ｒ Ｓ Ｎ Ｓ患儿以呼吸道病毒快速检验方法（桥联酶标法）对其不同阶段病毒的携带情况进行了检测，并以同期１８例呼吸道感染病患儿作为对照。结果： Ｓ Ｒ Ｓ Ｎ Ｓ患儿极期时呼吸道病毒携带率明显高于缓解期，呼吸道病毒检出率与尿蛋白定量密切相关（ Ｐ＜ ０．０５）。该病极期时和对照组相比，在病毒种类构成上无显著性差异（ Ｐ＞ ０．０５）。极期时病毒检出阳性的 Ｓ Ｒ Ｓ Ｎ Ｓ患儿中， Ｒ Ｎ Ａ 病毒占绝大部分（１３／１４），其中７８．５７％ （１１／１４）病毒检出阳性患儿并无呼吸道症状。上述结果提示， Ｓ Ｒ Ｓ Ｎ Ｓ患儿极期时呼吸道病毒携带率明显高于缓解期；不仅呼吸道病毒感染可导致激素敏感型单纯性肾病的触发，而且只要携带有呼吸道病毒，虽然并无呼吸道感染症状出现，也可引起该病触发。更多还原

【Abstract】 This study aimed to investigate the relationship between the carrying of respiratory tract viruses and the quantitative change of urinary protein of the steroid responsive and simple nephrotic syndrome (SRSNS), and to assess the function of respiratory tract viruses in the triggering of the SRSNS, 37 children with nephrotic syndrome underwent the examination of respiratory tract viruses (APAAP method) once a week when they were hospitalized from August 1997 to March 1998. Among them, 17 children had simple nephrotic syndrome and 10 had nephritic nephrosis. Moreover, 18 children with respiratory infection in the same season were chosen as the control and were subjected to the examination of respiratory tract viruses by the same method. In the cases of SRSNS, the percentage for the carrying of respiratory tract viruses increases obviously in the acme, the percentage for the carrying of respiratory tract viruses of SRSNS has close relationship with the quantity of urinary protein ( P <0.05). There is no difference between the constitution of the category of the viruses carried in the acme of SRSNS and that of the viruses in the control ( P >0.05). The most frequently detected respiratory tract viruses in the acme of SRSNS is RNA virus, and that in the control is the same( P >0.05). In the acme of SRSNS, most children have no symptoms of respiratory infection although respiratory tract viruses were detected. In the SRSNS, the percentage for the carrying of respiratory tract viruses increases obviously in the acme, it has an important relationship with the quantitative change of urinary protein. The category of the respiratory tract viruses detected in the SRSNS has a relationship with the season, this may be the reason why the cases of SRSNS so easily happen and relapse in this season. RNA virus perhaps plays an important role in the triggering of this disease, including the respiratory tract viruses infection and the carrying of respiratory tract viruses without the symptom of respiratory infection.更多还原