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类黄酮型缩杂环酮化合物的合成研究
STUDY ON SYNTHESIS OF FLAVONE LIKE HETEROCYELE FUSED TROPONOID COMPOUNDS
【摘要】 1前言黄酮类化合物广泛存在于植物体中,具有广泛的生物活性,其研究发展很快,特别是含氮黄酮类化合物具有抗癌、抗菌、冠状动脉扩张等作用[1]。但是,目前黄酮类药物仍然存在着两个问题,一是黄酮类化合物结构繁多,生物活性极其广泛,但作用强度普遍较弱;二是黄酮...
【Abstract】 Reported herein is a new method for the synthesis of Flavone like Heterocycle fused Troponoid Compounds by oxidizing Azo coupling products of 3 cinnamoyltropolone with Bromine in the presence of pyridine. Reaction of Azo couping products of 3 cinnamoyltropolone(1a~1d) with excess Bromine to afford 6 substitutedphenylazo 2 phenyl 8 bromine tropone(b)pyran 4,9 dione(2a~2d). Products 2a~2d are four new compounds their structures having been confirmed by elementary analysis and spectroscopic analysis.
【关键词】 3-肉桂酰基;
酚酮;
偶氮化合物;
溴氧化;
合成;
【Key words】 Cinnamoyltropolone; Azo coupling compounds; Bromine; Oxidation; Heterocycle fused troponoid compounds;
【Key words】 Cinnamoyltropolone; Azo coupling compounds; Bromine; Oxidation; Heterocycle fused troponoid compounds;
【基金】 辽宁省自然科学基金
- 【文献出处】 化学研究与应用 ,CHEMICAL RESEARCH AND APPLICATION , 编辑部邮箱 ,1999年01期
- 【分类号】O626.416
- 【下载频次】128