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取代芳甲酰哌嗪新衍生物的合成及其药理活性
SYNTHESIS AND POSITIVE INOTROPIC ACTIVITY OF SUBSTITUTED AROYL PIPERAZINE DERIVATIVES
【Abstract】 We designed and synthesized 5 new compounds. Their chemical structures were confirmed by means of MS, HNMR andelemental analysis. FPA was tested for positive inotropic activity. The results showed that FPA could increase the contrastive amplitudeof isolated atrium of guinea pigs and had no influence upon rhythm of the hearts.
【关键词】 取代芳甲酰基哌嗪衍生物;
正性肌力作用;
合成;
【Key words】 substitoted aroyl piperazine derivatives; positive inotropic activity; synthesis;
【Key words】 substitoted aroyl piperazine derivatives; positive inotropic activity; synthesis;
- 【文献出处】 化学研究与应用 ,CHEMICAL RESEARCH AND APPLICATION , 编辑部邮箱 ,1999年05期
- 【分类号】TQ463.5
- 【被引频次】4
- 【下载频次】60