【摘要】 目的：对测量甲硝唑根管消毒控释系统药物释放度的方法进行评价。方法：作体外释放实验、离体牙根周释药实验及自行设计的体内释药实验，求１、３、７、１０天的甲硝唑释放度，进行统计学分析。结果：体外与离体牙、体内实验的累积释药百分率在不同的时间均有极明显显著性差异（Ｐ＜０．０１）；离体牙与体内实验的累积释药百分率间无显著性差异（Ｐ＞０．０５）。结论：利用离体牙，将释放介质生理盐水控制在３７℃，ｐＨ７．４，测定甲硝唑释放度的方法更接近于体内情况，是一种测定根管消毒控释系统药物释放度的有效方法更多还原

【Abstract】 Objective: To measure the release rate of drug in controlled release delivery system containing metronidazole. Methods: Drug release tests in vitro, in vivo and through the roots of extracted teeth were performed. The release rate of metronidazole was calculated after 1 day, 3 days, 7 days and 10 days, and the results were statistically analyzed. Results: Significante difference was observed among the total drug release rate in vitro, in vivo and through the roots of extracted teeth (P<0 01). There was no statistically significant difference between the release test in vivo and through the roots of extracted teeth in vitro (P>0 05). Conclusion: The method of using extracted teeth and the controlled release medium at 37℃, pH7.4 was close to the situation in vivo, and it was an effective method to measure the drug release rate of the root canal disinfection controlled release delivery system.更多还原