【摘要】 以马来酸酐为原料二步法合成富马酸二甲酯。首先，马来酸酐水解异构化合成富马酸，采用一种新的异构化催化剂，反应的最优条件为15g马来酸酐和25ml水反应，加入0．1g催化剂，回流1h，产率为93．2％。然后，富马酸酯化合成富马酸二甲酯，采用对甲苯磺酸作催化剂，通过正交实验得到反应的最佳条件为：富马酸15g，对甲苯磺酸3g，醇酸摩尔比12：1，回流4h，产率67．5％。二步法的总产率可达62．9％。更多还原

【Abstract】 Dimethyl fumarate was prepared from maleic anhydride by two reaction steps. First, fumaric acid was yielded by hydrolysis and isomerization from maleic anhydride with a new catalyst. The yield of fumaric acid was 93.2% on the optimum condition of 15g of maleic anhydride, 25mL of water, 0. 1g of catalyst and reaction time being 1h. With the second step, dimethyl fumarate was yieldal by meth - esterificaion from fumaric acid. The catalyst of this reartion was p - toluene sulfonic acid. The optimum reaction condition obtained by means of orthogonal test was 15g of fumaric acid,3. 0g of p - toluene sulfonic acid, the mole ratioof methane alcohol to fumaric acid being 12 to 1 and reaction time being 4h .The yield of dimethyl fumaratewas 67.5% .The total yield of the two steps was 62.9%.更多还原