【摘要】 报道了５－硝基愈创木酚钠（５－ＮＧＳ）的合成方法。由愈创木酚与乙酐在１００℃回流１ ｈ 得到乙酰化产物。反应中生成的乙酸不必分离，再补加一定量乙酸作为下一步反应的溶剂。用发烟硝酸直接硝化上述乙酰化物，总收率高于７０％ 。用ＩＲ、１ＨＮＭＲ和ＭＳ对产物的结构进行了表征更多还原

【Abstract】 The synthesis of sodium 5 nitroguaiacolate (5 NGS) was studied by direct nitration of guaiacol acetate. Firstly, the guaiacol was acetylated by refluxing it with acetic anhydride and trace concentrated sulfuric acid as catalyst at 100℃ for 1 h. The acetic acid formed in the reaction needed not to remove and the stoichiometrical acetic acid which is as solvent for next reaction was added. The solution of guaiacol acetate in glacial acetic acid was nitrated by fuming nitric acid directly under 10℃. The total yield of 5 NGS obtained from experiments was above 70%. The structure of 5 NGS were also studied by IR, 1HNMR, and MS.更多还原