【摘要】 【目的】评估14 C 尿素呼吸试验 ( 14 C UBT)对幽门螺杆菌 (HP)感染的诊断价值 ,并探讨胃粘膜组织学变化对实验结果的影响。【方法】取 96例因上腹症状行胃镜检查的患者胃窦粘膜活检 ,分别行改良Giemsa染色和快速尿素酶 (RUT)试验 ,14 C UBT检查 ;将三项检查中两项 (或以上 )阳性者定为HP感染 ,分别对三种方法进行评价 ,并且观察其在不同胃粘膜病变中HP检出情况。【结果】14 C UBT的敏感性、特异性、符合率分别为 89.2 % ,98.3 % ,94.8% ,与组织学方法 (改良Giemsa染色为 91.9% ,93 .2 % ,92 .7% ,RUT为86 .5 % ,93 .2 % ,90 .6 % )比较差异无显著性 (均P >0 .0 5 ) ,同时不同胃粘膜病变对14 C UBT结果无明显影响。【结论】14 C UBT有较高的敏感性和特异性 ,是一可靠的非侵入性HP检测方法更多还原

【Abstract】 Objective To evaluate the efficiency of 14 C urea breath test( 14 C UBT) in the diagnosis of Helicobacterium pylori(HP) infection. Methods 14 C UBT was carried out in 96 patients subjected to gastroscopy owing to their symptomatic attacks of upper abdomen.The results were compared with those of HP histologic examination which included the rapid urease test(RUT)and modified Giemsa staining.Biopsy specimens were obtained from the gastric antrum by endoscopy. Results The sensitivity,specificity and accuracy of 14 C UBT were 89.2 %,98.3% and 94.8%,respectively.There were no significant differences as compared with those of histologic examination(RUT:86.5%,93.2% and 90.6 %;Giemsa staining:91.9%,93.2% and 92.7 %)(P>0.05).Moreover,These parameters of 14 C UBT were not affected by the pathologic changes in gastric mucosa. Conclusion These data showed that 14 C UBT is a reliable non invasive test and has an excellent sensitivity and specificity for the detection of HP infection.更多还原