【摘要】 目的： 探讨血源性乙型肝炎疫苗对乙型肝炎表面抗原（ ＨＢｓＡｇ） 阳性母亲的新生儿免疫持久性。方法：应用反向间接血凝反应（ ＲＰＨＡ） 法从１５００ 名孕妇中筛查出８２ 名ＨＢｓＡｇ ≥１∶６４ 的滴度阳性携带者的新生儿，分为疫苗组和对照组（ 人数比例为３∶１） 。疫苗组在新生儿出生２４ ｈ 内注射第１ 针，１ 月、６ 月龄分别注射第２ 针、３ 针乙肝疫苗，对照组按同样程序注射安慰剂。结果： 在第１３ 年时疫苗组抗ＨＢｓ 阳性率仍高达５９３２ ％ （３５／５９） ；对照组１３ 年中有２３５３ ％ （４／１７） 受到自然感染后变为抗ＨＢｓ 阳性，两组有显著性差异（ Ｐ＜ ００５） 。疫苗组的抗ＨＢｓ阳性者中，抗ＨＢｓＧＭＴ 峰值也在第１２ 个月，Ｓ／Ｎ 值为６８８４ ，到１３ 年时已下降到１７８２ ，相当于高峰的１／４ ，但仍明显高于对照组。除了出生时疫苗组与对照组ＨＢｓＡｇ 阳性率无明显差异外，疫苗组ＨＢｓＡｇ 阳性率一直明显低于对照组，在第１３ 年时疫苗组和对照组的ＨＢｓＡｇ 阳性率分别为６７７ ％ 、４７０６ ％ ，有显著性差异（ Ｐ＜ ００５） 。结论：ＨＢｓＡｇ 阳性母亲的新生儿进行乙型肝炎疫苗免疫１３ 年时，大部分仍有较好的?更多还原

【Abstract】 Objective:?To determine the immune persistence in neonates born to hepatitis B surface antigen (HBsAg) positive mothers with local produced plasmaderived HB immunization.Methods:?82 infants who were born by HBV carrier mothers were divided into two groups accrding to randomized,placebocontrolled method,one was vaccine group and another was controlled group(proportion of number was 3:1).The three doses of hepatitis B vaccine were injected on infants which were in vaccine group within 24 hours after born,first month and 6th month.It was the same in controlled group but vaccine was replaced by placebo.Results:?The rate of anti HBs positive in vaccine group reaches the peak(67.8% 40/59)on 12th month,then it come to decline slowly to 59.32%(35/59) on the 13th year.There are 23.53%(4/17)subjects become anti HBs positive in controlled group by natural infection.The difference between the groups are significant during the studying time.On the contrary with anti HBs,the rates of HBsAg are lower in vaccine group than controlled group during the time.They were 6.77% in vaccine group and 47.06% in controlled group respectively on the 13th year ( P <0.05).Conclusion:?The Perfect effect of hepatitis B vaccine is good even after 13 years of immunization.It is necessery to boost immunization to those whose anti HBs titer is low更多还原