【摘要】 目的：研究０－５ ｍｏｌ／Ｌ，１－５ ｍｏｌ／Ｌ和６－１ ｍｏｌ／Ｌ高渗ＮａＣｌ 溶液置栗鼠圆窗对内耳电生理和耳蜗血流的影响。方法：动物全身麻醉，暴露圆窗，分别放置０－５ ｍｏｌ／Ｌ，１－５ ｍｏｌ／Ｌ和６－１ ｍｏｌ／Ｌ的ＮａＣｌ 溶液棉片，观察２ ｈ 内听神经复合动作电位（ＣＡＰ） 阈值及耳蜗血流（ＣＢＦ） 改变情况。结果：０－５ ｍｏｌ／Ｌ，１－５ ｍｏｌ／Ｌ和６－１ ｍｏｌ／Ｌ三种ＮａＣｌ 溶液分别可提高ＣＢＦ７－６ ％ ，２４－５％ 和３５－３％ ，０－５ ｍｏｌ／Ｌ的ＮａＣｌ 溶液对ＣＡＰ阈值提高不明显，１－５ ｍｏｌ／Ｌ和６－１ ｍｏｌ／Ｌ的ＮａＣｌ溶液明显提高，以高频区为显著，二者相比以６－１ ｍｏｌ／ＬＮａＣｌ 溶液引起的听力损伤为重。结论：ＮａＣｌ 高渗溶液棉片置圆窗可增加耳蜗血流量；高渗ＮａＣｌ 溶液对内耳听功能的影响随浓度的增加而增大更多还原

【Abstract】 Aim:To investigate the influence on inner ear electrophysiology and cochlear blood flow caused by placing high osmotic sodium chloride (NaCl) solution in round window was observed.Methods:The cotton pieces absorbed high osmotic NaCl solution(0.5 mol/L,1 5 mol/L,6.1 mol/L)were put on round windows of chinchillas under general anesthesia separately.The changes of cochlear blood flow (CBF) and cochlear action potential(CAP)were observed.Results:The 0.5 mol/L,1.5 mol/L solution and 6.1 mol/L solution could enhance the CBF to 7.6%,24.5%and35.3%separately.After placing 1.5 mol/L solution and 6.1 mol/L solution the threshold of CAP rose obviously,especially in the field of high frequency.The threshold shift of CAP caused by 0.5 mol/L solution was not notable.Conclusion:This experiment confirms that NaCl solution could improve the circulation of inner ear.The influence of NaCl osmotic solution on hearing is getting serious with concentration rising.更多还原